Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.
Identifieur interne : 001485 ( Main/Exploration ); précédent : 001484; suivant : 001486Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.
Auteurs : Harri Lempi Inen [Suisse] ; Aino Uotila ; Jörg Urban ; Ilse Dohnal ; Gustav Ammerer ; Robbie Loewith ; David ShoreSource :
- Molecular cell [ 1097-4164 ] ; 2009.
Descripteurs français
- KwdFr :
- Cycloheximide (pharmacologie), Immunoprécipitation (MeSH), Immunoprécipitation de la chromatine (MeSH), Noyau de la cellule (métabolisme), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (génétique), Protein-Serine-Threonine Kinases (métabolisme), Protéines adaptatrices de la transduction du signal (MeSH), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines de liaison à l'ADN (génétique), Protéines de liaison à l'ADN (métabolisme), Régions promotrices (génétique) (génétique), Rétrocontrôle physiologique (physiologie), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Sirolimus (pharmacologie).
- MESH :
- croissance et développement : Saccharomyces cerevisiae.
- génétique : Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Protéines de liaison à l'ADN, Régions promotrices (génétique), Saccharomyces cerevisiae.
- métabolisme : Noyau de la cellule, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Protéines de liaison à l'ADN, Saccharomyces cerevisiae.
- pharmacologie : Cycloheximide, Sirolimus.
- physiologie : Rétrocontrôle physiologique.
- Immunoprécipitation, Immunoprécipitation de la chromatine, Phosphorylation, Protéines adaptatrices de la transduction du signal.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (MeSH), Cell Nucleus (metabolism), Chromatin Immunoprecipitation (MeSH), Cycloheximide (pharmacology), DNA-Binding Proteins (genetics), DNA-Binding Proteins (metabolism), Feedback, Physiological (physiology), Immunoprecipitation (MeSH), Phosphorylation (MeSH), Promoter Regions, Genetic (genetics), Protein-Serine-Threonine Kinases (genetics), Protein-Serine-Threonine Kinases (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Sirolimus (pharmacology).
- MESH :
- chemical , genetics : DNA-Binding Proteins, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : DNA-Binding Proteins, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- chemical , pharmacology : Cycloheximide, Sirolimus.
- chemical : Adaptor Proteins, Signal Transducing.
- genetics : Promoter Regions, Genetic, Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Cell Nucleus, Saccharomyces cerevisiae.
- physiology : Feedback, Physiological.
- Chromatin Immunoprecipitation, Immunoprecipitation, Phosphorylation.
Abstract
Ribosome biogenesis drives cell growth, and the large transcriptional output underlying this process is tightly regulated. The Target of Rapamycin (TOR) kinase is part of a highly conserved signaling pathway linking nutritional and stress signals to regulation of ribosomal protein (RP) and ribosome biogenesis (Ribi) gene transcription. In Saccharomyces cerevisiae, one of the downstream effectors of TOR is Sfp1, a transcriptional activator that regulates both RP and Ribi genes. Here, we report that Sfp1 interacts directly with TOR complex 1 (TORC1) in a rapamycin-regulated manner, and that phosphorylation of Sfp1 by this kinase complex regulates its function. Sfp1, in turn, negatively regulates TORC1 phosphorylation of Sch9, another key TORC1 target that acts in parallel with Sfp1, revealing a feedback mechanism controlling the activity of these proteins. Finally, we show that the Sfp1-interacting protein Mrs6, a Rab escort protein involved in membrane trafficking, regulates both Sfp1 nuclear localization and TORC1 signaling.
DOI: 10.1016/j.molcel.2009.01.034
PubMed: 19328065
Affiliations:
Links toward previous steps (curation, corpus...)
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The Target of Rapamycin (TOR) kinase is part of a highly conserved signaling pathway linking nutritional and stress signals to regulation of ribosomal protein (RP) and ribosome biogenesis (Ribi) gene transcription. In Saccharomyces cerevisiae, one of the downstream effectors of TOR is Sfp1, a transcriptional activator that regulates both RP and Ribi genes. Here, we report that Sfp1 interacts directly with TOR complex 1 (TORC1) in a rapamycin-regulated manner, and that phosphorylation of Sfp1 by this kinase complex regulates its function. Sfp1, in turn, negatively regulates TORC1 phosphorylation of Sch9, another key TORC1 target that acts in parallel with Sfp1, revealing a feedback mechanism controlling the activity of these proteins. Finally, we show that the Sfp1-interacting protein Mrs6, a Rab escort protein involved in membrane trafficking, regulates both Sfp1 nuclear localization and TORC1 signaling.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19328065</PMID><DateCompleted><Year>2009</Year><Month>04</Month><Day>16</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1097-4164</ISSN><JournalIssue CitedMedium="Internet"><Volume>33</Volume><Issue>6</Issue><PubDate><Year>2009</Year><Month>Mar</Month><Day>27</Day></PubDate></JournalIssue><Title>Molecular cell</Title><ISOAbbreviation>Mol Cell</ISOAbbreviation></Journal><ArticleTitle>Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.</ArticleTitle><Pagination><MedlinePgn>704-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.molcel.2009.01.034</ELocationID><Abstract><AbstractText>Ribosome biogenesis drives cell growth, and the large transcriptional output underlying this process is tightly regulated. The Target of Rapamycin (TOR) kinase is part of a highly conserved signaling pathway linking nutritional and stress signals to regulation of ribosomal protein (RP) and ribosome biogenesis (Ribi) gene transcription. In Saccharomyces cerevisiae, one of the downstream effectors of TOR is Sfp1, a transcriptional activator that regulates both RP and Ribi genes. Here, we report that Sfp1 interacts directly with TOR complex 1 (TORC1) in a rapamycin-regulated manner, and that phosphorylation of Sfp1 by this kinase complex regulates its function. Sfp1, in turn, negatively regulates TORC1 phosphorylation of Sch9, another key TORC1 target that acts in parallel with Sfp1, revealing a feedback mechanism controlling the activity of these proteins. Finally, we show that the Sfp1-interacting protein Mrs6, a Rab escort protein involved in membrane trafficking, regulates both Sfp1 nuclear localization and TORC1 signaling.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lempiäinen</LastName><ForeName>Harri</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology, University of Geneva, 30 quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uotila</LastName><ForeName>Aino</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Urban</LastName><ForeName>Jörg</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Dohnal</LastName><ForeName>Ilse</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Ammerer</LastName><ForeName>Gustav</ForeName><Initials>G</Initials></Author><Author 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sortKey="Dohnal, Ilse" sort="Dohnal, Ilse" uniqKey="Dohnal I" first="Ilse" last="Dohnal">Ilse Dohnal</name><name sortKey="Loewith, Robbie" sort="Loewith, Robbie" uniqKey="Loewith R" first="Robbie" last="Loewith">Robbie Loewith</name><name sortKey="Shore, David" sort="Shore, David" uniqKey="Shore D" first="David" last="Shore">David Shore</name><name sortKey="Uotila, Aino" sort="Uotila, Aino" uniqKey="Uotila A" first="Aino" last="Uotila">Aino Uotila</name><name sortKey="Urban, Jorg" sort="Urban, Jorg" uniqKey="Urban J" first="Jörg" last="Urban">Jörg Urban</name></noCountry><country name="Suisse"><region name="Canton de Genève"><name sortKey="Lempi Inen, Harri" sort="Lempi Inen, Harri" uniqKey="Lempi Inen H" first="Harri" last="Lempi Inen">Harri Lempi Inen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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